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PARP1 antibody (pSer373)

PARP1 Reactivity: Rat DB Host: Rabbit Polyclonal RB40136 unconjugated
Catalog No. ABIN1881626
  • Target See all PARP1 Antibodies
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Binding Specificity
    • 20
    • 17
    • 16
    • 15
    • 12
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer373
    Reactivity
    • 232
    • 64
    • 48
    • 8
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Rat
    Host
    • 220
    • 27
    • 1
    • 1
    Rabbit
    Clonality
    • 207
    • 42
    Polyclonal
    Conjugate
    • 143
    • 17
    • 16
    • 16
    • 15
    • 14
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    This PARP1 antibody is un-conjugated
    Application
    • 161
    • 130
    • 68
    • 39
    • 34
    • 28
    • 28
    • 24
    • 24
    • 17
    • 16
    • 7
    • 7
    • 3
    • 2
    • 2
    • 1
    Dot Blot (DB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This rat PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S373 of rat PARP1.
    Clone
    RB40136
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PARP1 Primary Antibody
  • Application Notes
    DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Beneke, Scherr, Ponath, Popp, Bürkle: "Enzyme characteristics of recombinant poly(ADP-ribose) polymerases-1 of rat and human origin mirror the correlation between cellular poly(ADP-ribosyl)ation capacity and species-specific life span." in: Mechanisms of ageing and development, Vol. 131, Issue 5, pp. 366-9, (2010) (PubMed).

    Kondo, Obitsu, Ohta, Matsunami, Otsuka, Teshima: "Poly(ADP-ribose) polymerase (PARP)-1-independent apoptosis-inducing factor (AIF) release and cell death are induced by eleostearic acid and blocked by alpha-tocopherol and MEK inhibition." in: The Journal of biological chemistry, Vol. 285, Issue 17, pp. 13079-91, (2010) (PubMed).

    Zaalishvili, Margiani, Kutalia, Suladze, Zaalishvili: "Automodification of PARP-1 mediates its tight binding to the nuclear matrix." in: Biochemical and biophysical research communications, Vol. 393, Issue 1, pp. 123-5, (2010) (PubMed).

    Drel, Xu, Zhang, Pavlov, Shevalye, Slusher, Obrosova: "Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy." in: Endocrinology, Vol. 150, Issue 12, pp. 5273-83, (2009) (PubMed).

    Adamczyk, Kaźmierczak: "Alpha-synuclein inhibits poly (ADP-ribose) polymerase-1 (PARP-1) activity via NO-dependent pathway." in: Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences, Vol. 47, Issue 3, pp. 247-51, (2009) (PubMed).

  • Target
    PARP1 (Poly (ADP-Ribose) Polymerase 1 (PARP1))
    Alternative Name
    PARP1 (PARP1 Products)
    Synonyms
    ADPRT antibody, ADPRT 1 antibody, ADPRT1 antibody, ARTD1 antibody, PARP antibody, PARP-1 antibody, PPOL antibody, pADPRT-1 antibody, Adprt antibody, Parp-1 antibody, 5830444G22Rik antibody, AI893648 antibody, Adprp antibody, Adprt1 antibody, C80510 antibody, parp-1 antibody, sPARP-1 antibody, BEST:LD21673 antibody, CG17685 antibody, CG17696 antibody, CG17718 antibody, CG40411 antibody, D.PARP antibody, Dm.pARTa antibody, Dmel\\CG40411 antibody, LD21673.3prime antibody, PARP1 antibody, dPARP antibody, parp antibody, adprt1 antibody, padprt-1 antibody, ppol antibody, si:dkey-206f10.3 antibody, wu:fc60f12 antibody, zgc:110092 antibody, poly(ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase family, member 1 antibody, Poly-(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 1 L homeolog antibody, PARP1 antibody, Parp1 antibody, Parp antibody, parp1.L antibody, parp1 antibody
    Background
    Catalyzes poly (ADP-ribose) protein modification, plays a role in DNA repair and genome stability [RGD].
    Molecular Weight
    112660
    NCBI Accession
    NP_037195
    UniProt
    P27008
    Pathways
    Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair, Production of Molecular Mediator of Immune Response, Maintenance of Protein Location
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