PPP2CA antibody (AA 88-116)

Catalog No. ABIN1881681

Cited in 4+ publications. The Rabbit Polyclonal anti-PPP2CA antibody (Clone RB41800) (ABIN1881681) specifically detects PPP2CA in WB. The antibody is reactive with Mouse samples.

Quick Overview for PPP2CA antibody (AA 88-116) (ABIN1881681)

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2CA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41800

Product Details anti-PPP2CA Antibody

Binding Specificity: AA 88-116

Predicted Reactivity: B, Pig, Rb, Rat, D

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PPP2CA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the Central region of human PPP2CA.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PPP2CA antibody (ABIN1881681)

Pradhan, Alrehani, Patel, Khatlani, Vijayan: "Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen." in: The Journal of biological chemistry, Vol. 285, Issue 38, pp. 29059-68, (2010) (PubMed).

Schmitz, Held, Janssens, Hutchins, Hudecz, Ivanova, Goris, Trinkle-Mulcahy, Lamond, Poser, Hyman, Mechtler, Peters, Gerlich: "Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells." in: Nature cell biology, Vol. 12, Issue 9, pp. 886-93, (2010) (PubMed).

Antony, Lukiw, Bazan: "Neuroprotectin D1 induces dephosphorylation of Bcl-xL in a PP2A-dependent manner during oxidative stress and promotes retinal pigment epithelial cell survival." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18301-8, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Target Details for PPP2CA

Target: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Alternative Name: PPP2CA

Background: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.

Molecular Weight: 35594

NCBI Accession: NP_002706

UniProt: P67775

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades