SMAD6 antibody (C-Term)

Catalog No. ABIN1881817

This Rabbit Polyclonal antibody specifically detects SMAD6 in WB. It exhibits reactivity toward Mouse and has been mentioned in 2+ publications.

Quick Overview for SMAD6 antibody (C-Term) (ABIN1881817)

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD6 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41931

Product Details anti-SMAD6 Antibody

Binding Specificity: AA 357-386, C-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SMAD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-386 amino acids from the C-terminal region of human SMAD6.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SMAD6 antibody (ABIN1881817)

Ryan, Ryan, Fabre, Lawless, Crowe: "Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1266-73, (2010) (PubMed).

Yu, Mrowietz, Seifert: "Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin." in: Acta dermato-venereologica, Vol. 89, Issue 4, pp. 351-6, (2009) (PubMed).

Target Details for SMAD6

Target: SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))

Alternative Name: SMAD6

Background: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 53497

NCBI Accession: NP_001136333, NP_005576

UniProt: O43541

Pathways: Chromatin Binding