TICAM1 antibody (N-Term)

Catalog No. ABIN1881885

Cited in 5+ publications. The Rabbit Polyclonal anti-TICAM1 antibody (ABIN1881885) specifically detects TICAM1 in WB. The antibody is reactive with Human and Mouse samples.

Quick Overview for TICAM1 antibody (N-Term) (ABIN1881885)

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TICAM1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TICAM1 Antibody

Binding Specificity: AA 115-143, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TICAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-143 amino acids from the N-terminal region of human TICAM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TICAM1 antibody (ABIN1881885)

Nakajima, Ohtani, Satta, Uno, Akari, Ishida, Kimura: "Natural selection in the TLR-related genes in the course of primate evolution." in: Immunogenetics, Vol. 60, Issue 12, pp. 727-35, (2008) (PubMed).

Bin, Xu, Shu: "TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling." in: The Journal of biological chemistry, Vol. 278, Issue 27, pp. 24526-32, (2003) (PubMed).

Oshiumi, Matsumoto, Funami, Akazawa, Seya: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." in: Nature immunology, Vol. 4, Issue 2, pp. 161-7, (2003) (PubMed).

Matsuda, Suzuki, Honda, Muramatsu, Matsuzaki, Nagano, Doi, Shimotohno, Harada, Nishida, Hayashi, Sugano: "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways." in: Oncogene, Vol. 22, Issue 21, pp. 3307-18, (2003) (PubMed).

Yamamoto, Sato, Mori, Hoshino, Takeuchi, Takeda, Akira: "Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 12, pp. 6668-72, (2002) (PubMed).

Target Details for TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Alternative Name: TICAM1

Background: Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively.

Molecular Weight: 76422

NCBI Accession: NP_891549

UniProt: Q8IUC6

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades