TXNIP antibody (AA 116-145)
-
- Target See all TXNIP Antibodies
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
-
Binding Specificity
- AA 116-145
-
Reactivity
- Mouse
-
Host
- Rabbit
-
Clonality
- Polyclonal
-
Conjugate
- This TXNIP antibody is un-conjugated
-
Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Predicted Reactivity
- Rat
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.
- Clone
- RB30652
- Isotype
- Ig Fraction
- Top Product
- Discover our top product TXNIP Primary Antibody
-
-
- Application Notes
- WB: 1:2000. IHC-P: 1:100
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
-
-
[Growing old]." in: Revue médicale suisse, Vol. 6, Issue 256, pp. 1424, (2010) (PubMed).
: "The role of vitamin D3 upregulated protein 1 in thioacetamide-induced mouse hepatotoxicity." in: Toxicology and applied pharmacology, Vol. 248, Issue 3, pp. 277-84, (2010) (PubMed).
: "Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3980-9, (2010) (PubMed).
: "p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells." in: FEBS letters, Vol. 584, Issue 15, pp. 3480-5, (2010) (PubMed).
: "TXNIP regulates germinal center generation by suppressing BCL-6 expression." in: Immunology letters, Vol. 129, Issue 2, pp. 78-84, (2010) (PubMed).
: "
-
[Growing old]." in: Revue médicale suisse, Vol. 6, Issue 256, pp. 1424, (2010) (PubMed).
-
- Target
- TXNIP (Thioredoxin Interacting Protein (TXNIP))
- Alternative Name
- Txnip (TXNIP Products)
- Synonyms
- EST01027 antibody, HHCPA78 antibody, THIF antibody, VDUP1 antibody, Gm348 antibody, Trf3 antibody, TBP2 antibody, TRF3 antibody, 1200008J08Rik antibody, AA682105 antibody, Hyplip1 antibody, Tbp-2 antibody, Vdup1 antibody, sb:cb368 antibody, txnip antibody, thioredoxin interacting protein antibody, TATA box binding protein like 2 antibody, TATA-box binding protein like 2 antibody, thioredoxin interacting protein L homeolog antibody, thioredoxin interacting protein a antibody, TXNIP antibody, Tbpl2 antibody, TBPL2 antibody, Txnip antibody, txnip.L antibody, txnip antibody, txnipa antibody
- Background
- May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
- Molecular Weight
- 44363
- NCBI Accession
- NP_001009935, NP_076208
- UniProt
- Q8BG60
- Pathways
- Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome
-