DUSP6 antibody

Catalog No. ABIN1882185

This anti-DUSP6 antibody is a Rabbit Polyclonal antibody detecting DUSP6 in WB and FACS. Suitable for Rat. This Primary Antibody has been cited in 3+ publications.

Quick Overview for DUSP6 antibody (ABIN1882185)

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP6 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: RB7281

Product Details anti-DUSP6 Antibody

Purification: This antibody is purified through a protein A column, followed by dialysis against PBS.

Immunogen: This Rat MKP3 antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1~381 of rat MKP3.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DUSP6 antibody (ABIN1882185)

Olson, Protheroe, Segar, Scholz: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, (2006) (PubMed).

Muda, Boschert, Dickinson, Martinou, Martinou, Camps, Schlegel, Arkinstall: "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 4319-26, (1996) (PubMed).

Mourey, Vega, Campbell, Wenderoth, Hauschka, Krebs, Dixon: "A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation." in: The Journal of biological chemistry, Vol. 271, Issue 7, pp. 3795-802, (1996) (PubMed).

Target Details for DUSP6

Target: DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))

Alternative Name: MKP3

Background: Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36 % identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis

Molecular Weight: 42319

NCBI Accession: NP_446335

UniProt: Q64346

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades