LOX antibody (AA 234-260)

Catalog No. ABIN1882262

There are 2+ publications for this product available. The Mouse Monoclonal anti-LOX antibody is suitable to detect LOX in samples from Human. It has been validated for WB.

Quick Overview for LOX antibody (AA 234-260) (ABIN1882262)

Target: LOX (Lysyl Oxidase (LOX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LOX antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 624CT23-7-3

Product Details anti-LOX Antibody

Binding Specificity: AA 234-260

Predicted Reactivity: M, Pig, Rat

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This LOX antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 234-260 amino acids from the Central region of human LOX.

Isotype: IgG2b

Application Details

Application Notes: WB: 1:100~500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LOX antibody (ABIN1882262)

Gao, Xiao, Ma, Li, Liu, Feng, Fang, Wu, Han, Zhang, Sun, Wu, Padera, Chen, Wong, Ge, Ji: "LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 44, pp. 18892-7, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Target Details for LOX

Target: LOX (Lysyl Oxidase (LOX))

Alternative Name: LOX

Background: The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 46944

NCBI Accession: NP_002308

UniProt: P28300

Pathways: SARS-CoV-2 Protein Interactome