APEX1 antibody (AA 1-15)

Catalog No. ABIN1885631

The Rabbit Polyclonal anti-APEX1 antibody is suitable to detect APEX1 in samples from Human. It has been validated for WB and IF.

Quick Overview for APEX1 antibody (AA 1-15) (ABIN1885631)

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APEX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-APEX1 Antibody

Binding Specificity: AA 1-15

Purification: Affinity purified by Protein A.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 1 and 15 of APE1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for APEX1

Target: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Alternative Name: APE1

Background: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases.AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites.Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site.This gene encodes the major AP endonuclease in human cells.Splice variants have been found for this gene, all encode the same protein.[provided by RefSeq]
Synonyms: APE, APE-1, APE1, APEN, APEX, APX, HAP1, REF-1, REF1

Molecular Weight: 36 kDa

Gene ID: 328

NCBI Accession: NP_001632, NM_001641

Pathways: DNA Damage Repair, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus