FGFRL1 antibody (AA 150-486)

Catalog No. ABIN1886062

This Rabbit Polyclonal antibody specifically detects FGFRL1 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for FGFRL1 antibody (AA 150-486) (ABIN1886062)

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFRL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-FGFRL1 Antibody

Binding Specificity: AA 150-486

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 150 and 486 of Human FGFRL1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for FGFRL1

Target: FGFRL1 (Fibroblast Growth Factor Receptor-Like 1 (FGFRL1))

Alternative Name: FGFR-5

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution.FGFR family members differ from one another in their ligand affinities and tissue distribution.A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain.The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling.Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene.[provided by RefSeq]

Molecular Weight: 55 kDa

Gene ID: 53834

NCBI Accession: NP_001004356, NM_001004356

Pathways: RTK Signaling