MMP2 antibody (AA 193-545)

Catalog No. ABIN1886151

This anti-MMP2 antibody is a Rabbit Polyclonal antibody detecting MMP2 in WB and IF. Suitable for Human.

Quick Overview for MMP2 antibody (AA 193-545) (ABIN1886151)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-MMP2 Antibody

Binding Specificity: AA 193-545

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 193 and 545 of Human MMP2

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: MMP2

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes.The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response.Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome.Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]

Molecular Weight: 74 kDa

Gene ID: 4313

NCBI Accession: NM_004530, NP_004521

Pathways: Activation of Innate immune Response