DMBT1 antibody (AA 2025-2273)

Catalog No. ABIN1886177

The Rabbit Polyclonal anti-DMBT1 antibody is suitable to detect DMBT1 in samples from Human. It has been validated for WB.

Quick Overview for DMBT1 antibody (AA 2025-2273) (ABIN1886177)

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DMBT1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DMBT1 Antibody

Binding Specificity: AA 2025-2273

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 2025 and 2273 of Human DMBT1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for DMBT1

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Alternative Name: gp340

Background: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers.The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line.DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized.The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID).Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition.This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.[provided by RefSeq]

Molecular Weight: 260 kDa

Gene ID: 1755

NCBI Accession: NM_017579, NP_060049

Pathways: Activation of Innate immune Response