TPP1 antibody (AA 224-562)

Catalog No. ABIN1886223

The Rabbit Polyclonal anti-TPP1 antibody (ABIN1886223) specifically detects TPP1 in WB. The antibody is reactive with Human samples.

Quick Overview for TPP1 antibody (AA 224-562) (ABIN1886223)

Target: TPP1 (Tripeptidyl Peptidase I (TPP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TPP1 Antibody

Binding Specificity: AA 224-562

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 224 and 562 of CLN2

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for TPP1

Target: TPP1 (Tripeptidyl Peptidase I (TPP1))

Alternative Name: CLN2

Background: This gene encodes a member of the sedolisin family of serine proteases.The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity.It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification.Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.[provided by RefSeq]

Molecular Weight: 61 kDa

Gene ID: 1200

NCBI Accession: NP_000382, NM_000391

Pathways: Cell Division Cycle, ER-Nucleus Signaling