MC1 Receptor antibody (AA 253-317)

Catalog No. ABIN1886268

This anti-MC1 Receptor antibody is a Rabbit Polyclonal antibody detecting MC1 Receptor in WB. Suitable for Human.

Quick Overview for MC1 Receptor antibody (AA 253-317) (ABIN1886268)

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MC1 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MC1 Receptor Antibody

Binding Specificity: AA 253-317

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 253 and 317 of Human MC1R

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for MC1 Receptor

Target: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Alternative Name: MC1-R

Background: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH).The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis.Two types of melanin exist: red pheomelanin and black eumelanin.Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color.Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation.Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis.This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.[provided by RefSeq]
Synonyms: MSH-R, SHEP2, MGC14337

Molecular Weight: 35 kDa

Gene ID: 4157

NCBI Accession: NM_002386, NP_002377

Pathways: cAMP Metabolic Process, Feeding Behaviour