MCM3 antibody (AA 42-272)

Catalog No. ABIN1886459

The Rabbit Polyclonal anti-MCM3 antibody is suitable to detect MCM3 in samples from Human. It has been validated for WB, IHC and IF.

Quick Overview for MCM3 antibody (AA 42-272) (ABIN1886459)

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCM3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MCM3 Antibody

Binding Specificity: AA 42-272

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 42 and 272 of MCM3

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for MCM3

Target: MCM3 (Minichromosome Maintenance Complex Component 3 (MCM3))

Alternative Name: MCM3

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication.The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.This protein is a subunit of the protein complex that consists of MCM2-7.It has been shown to interact directly with MCM5/CDC46.This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase.The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.[provided by RefSeq]

Molecular Weight: 91 kDa

Gene ID: 4172

NCBI Accession: NM_002388, NP_002379

Pathways: DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA