Acetylcholinesterase antibody (AA 551-614)

Catalog No. ABIN1886552

The Rabbit Polyclonal anti-Acetylcholinesterase antibody is suitable to detect Acetylcholinesterase in samples from Human. It has been validated for WB and IF.

Quick Overview for Acetylcholinesterase antibody (AA 551-614) (ABIN1886552)

Target: Acetylcholinesterase (AChE)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetylcholinesterase antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Acetylcholinesterase Antibody

Binding Specificity: AA 551-614

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 551 and 614 of Human ACHE

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Acetylcholinesterase

Target: Acetylcholinesterase (AChE)

Alternative Name: AChE

Background: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission.It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen.Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface.It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits.The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits.The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site.It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally.[provided by RefSeq]

Molecular Weight: 68 kDa

Gene ID: 43

NCBI Accession: NP_000656, NM_000665

Pathways: Skeletal Muscle Fiber Development