IL12RB1 antibody (AA 57-458)

Catalog No. ABIN1886561

The Rabbit Polyclonal anti-IL12RB1 antibody has been validated for WB. It is suitable to detect IL12RB1 in samples from Human.

Quick Overview for IL12RB1 antibody (AA 57-458) (ABIN1886561)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12RB1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-IL12RB1 Antibody

Binding Specificity: AA 57-458

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 57 and 458 of Human IL12RB1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Background: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily.This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex.This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity.The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling.The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections.Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.[provided by RefSeq]

Molecular Weight: 73 kDa

Gene ID: 3594

NCBI Accession: NM_005535, NP_005526

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation