Lamin A/C antibody (AA 59-259)

Catalog No. ABIN1886567

The Rabbit Polyclonal anti-Lamin A/C antibody has been validated for WB and IHC. It is suitable to detect Lamin A/C in samples from Human.

Quick Overview for Lamin A/C antibody (AA 59-259) (ABIN1886567)

Target: Lamin A/C (LMNA)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Lamin A/C Antibody

Binding Specificity: AA 59-259

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 259 of Lamin A/C

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: Lamin A/C

Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.The lamin family of proteins make up the matrix and are highly conserved in evolution.During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated.Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.Vertebrate lamins consist of two types, A and B.Through alternate splicing, this gene encodes three type A lamin isoforms.Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.[provided by RefSeq]

Molecular Weight: 65 kDa

Gene ID: 4000

NCBI Accession: NP_005563, NM_005572

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus