TYK2 antibody (AA 680-1176)

Catalog No. ABIN1886613

The Rabbit Polyclonal anti-TYK2 antibody (ABIN1886613) specifically detects TYK2 in WB and IF. The antibody is reactive with Human samples.

Quick Overview for TYK2 antibody (AA 680-1176) (ABIN1886613)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-TYK2 Antibody

Binding Specificity: AA 680-1176

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 680 and 1176 of TYK2

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: TYK2

Background: This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families.This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits.It is also component of both the type I and type III interferon signaling pathways.As such, it may play a role in anti-viral immunity.A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.[provided by RefSeq]

Molecular Weight: 134 kDa

Gene ID: 7297

NCBI Accession: NM_003331, NP_003322

Pathways: JAK-STAT Signaling, Hepatitis C