DNASE2 antibody (AA 347-360)

Catalog No. ABIN1886871

The Rabbit Polyclonal anti-DNASE2 antibody (ABIN1886871) specifically detects DNASE2 in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for DNASE2 antibody (AA 347-360) (ABIN1886871)

Target: DNASE2 (Deoxyribonuclease II, Lysosomal (DNASE2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNASE2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-DNASE2 Antibody

Binding Specificity: AA 347-360

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 347 to 360 of human DNase II precursor (2-4).

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for DNASE2

Target: DNASE2 (Deoxyribonuclease II, Lysosomal (DNASE2))

Alternative Name: DNase II

Background: Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation.These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus.DNase II causes both chromatin condensation and DNA fragmentation.The genes encoding human, porcine, and murine DNase II have been cloned.The DNase II gene encodes a 40 kDa proenzyme.The mature enzyme consists of two non-identical subunits, the 32 kDa (alpha) and 12 kDa (beta) chains, generated by proteolytic processing.Overexpression of DNase II induces chromatin condensation.DNase II is ubiquitously expressed in human tissues.
Synonyms: DNase II

Molecular Weight: 40 kDa