IL1RAP antibody (AA 525-540)

Catalog No. ABIN1886887

This Rabbit Polyclonal antibody specifically detects IL1RAP in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for IL1RAP antibody (AA 525-540) (ABIN1886887)

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL1RAP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL1RAP Antibody

Binding Specificity: AA 525-540

Cross-Reactivity (Details): This polyclonal antibody has no cross activity to other members in the IL-1 receptor family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Peptide corresponding to amino acids 525 to 540 of human IL-1RAcP, which is identical to those of mouse and rat origins.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for IL1RAP

Target: IL1RAP (Interleukin 1 Receptor Accessory Protein (IL1RAP))

Alternative Name: IL-1RAcP

Background: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP).IL-1RAcP forms a complex with IL-1RI in response to IL-1 treatment.The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kappaB inducing kinae (NIK) and of NF-kappaB, recruits to the IL-1R complex through IL-1RAcP.IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP.Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response.IL-1RAcP is expressed in many tissues.
Synonyms: IL-1RAcP

Molecular Weight: 66 kDa

Pathways: NF-kappaB Signaling, Growth Factor Binding