Caspase 4 antibody (AA 91-105)

Catalog No. ABIN1886902

This Rabbit Polyclonal antibody specifically detects Caspase 4 in WB, IHC and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Caspase 4 antibody (AA 91-105) (ABIN1886902)

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Caspase 4 Antibody

Binding Specificity: AA 91-105

Purification: Ion exchange chromatography purified

Immunogen: Peptide corresponding to amino acids 91 to 105 of human caspase-13.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for Caspase 4

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Alternative Name: Caspase-13

Background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases.A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13.Caspase-13 belongs to the ICE subfamily of caspases.Overexpression of caspase-13 induces apoptosis.Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis.Caspase-13 is expressed in a variety of human tissues and cell lines.
Synonyms: Casp-13, ERICE

Molecular Weight: 43 kDa

UniProt: O75601

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity