Angiotensin II Type-1 Receptor antibody (Internal Region)

Catalog No. ABIN190902

The Goat Polyclonal anti-Angiotensin II Type-1 Receptor antibody (ABIN190902) specifically detects Angiotensin II Type-1 Receptor in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for Angiotensin II Type-1 Receptor antibody (Internal Region) (ABIN190902)

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Reactivity: Human, Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This Angiotensin II Type-1 Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Verified

Product Details anti-Angiotensin II Type-1 Receptor Antibody

Binding Specificity: Internal Region

Purpose: AGTR1 / AT1

Sequence: EIQKNKPRND DIFK

Specificity: All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1).

Cross-Reactivity: Human, Mouse

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-EIQKNKPRNDDIFK, from the internal region of the protein sequence according to NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1, NP_114438.1.

Isotype: IgG

Application Details

Application Notes:

Western Blot: Approx 38 kDa band observed in Human and Mouse Liver lysates (calculated MW of 41.1 kDa according to Human NP_000676.1 and 40.9 kDa according to Mouse NP_796296.1) Additional bands of unknown identity were also observed at 45 and 75 kDakDa an

Peptide ELISA: antibody detection limit dilution 1:32000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.

Target Details for Angiotensin II Type-1 Receptor

Target: Angiotensin II Type-1 Receptor (AGTR1) (Angiotensin II Receptor, Type 1 (AGTR1))

Alternative Name: AGTR1

Background: AGTR1, AT1, angiotensin II receptor, type 1 , AG2S, AGTR1A, AGTR1B, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R, angiotensin receptor 1, angiotensin receptor 1B, type-1B angiotensin II receptor

Gene ID: 185, 11607, 24180

NCBI Accession: NP_000676, NP_004826, NP_033611, NP_114038, NP_114438

Pathways: JAK-STAT Signaling, ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour