TFAP2A antibody (AA 134-166)

Catalog No. ABIN1945094

There are 4+ publications for this product available. The Rabbit Polyclonal anti-TFAP2A antibody is suitable to detect TFAP2A in samples from Mouse. It has been validated for WB.

Quick Overview for TFAP2A antibody (AA 134-166) (ABIN1945094)

Target: TFAP2A (Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFAP2A antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB43450

Product Details anti-TFAP2A Antibody

Binding Specificity: AA 134-166

Predicted Reactivity: B, Rat, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This mouse Tfap2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the Central region of mouse Tfap2a.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TFAP2A antibody (ABIN1945094)

Yahata, Takedatsu, Dunwoodie, Bragança, Swingler, Withington, Hur, Coser, Isselbacher, Bhattacharya, Shioda: "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells." in: Genomics, Vol. 80, Issue 6, pp. 601-13, (2002) (PubMed).

Meier, Koedood, Philipp, Fontana, Mitchell: "Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis." in: Developmental biology, Vol. 169, Issue 1, pp. 1-14, (1995) (PubMed).

Moser, Pscherer, Bauer, Imhof, Seegers, Kerscher, Buettner: "The complete murine cDNA sequence of the transcription factor AP-2." in: Nucleic acids research, Vol. 21, Issue 20, pp. 4844, (1993) (PubMed).

Mitchell, Timmons, Hébert, Rigby, Tjian: "Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis." in: Genes & development, Vol. 5, Issue 1, pp. 105-19, (1991) (PubMed).

Target Details for TFAP2A

Target: TFAP2A (Transcription Factor AP-2 alpha (Activating Enhancer Binding Protein 2 Alpha) (TFAP2A))

Alternative Name: Tfap2a

Background: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

Molecular Weight: 47971

Gene ID: 21418

UniProt: P34056

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Response to Water Deprivation, Sensory Perception of Sound, Tube Formation, Embryonic Body Morphogenesis, Brown Fat Cell Differentiation, Lipid Metabolism