SOCS1 antibody (AA 1-211) (FITC)

Catalog No. ABIN1994213

The Rabbit Polyclonal anti-SOCS1 antibody has been validated for WB and ELISA. It is suitable to detect SOCS1 in samples from Human.

Quick Overview for SOCS1 antibody (AA 1-211) (FITC) (ABIN1994213)

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SOCS1 antibody is conjugated to FITC

Application: Western Blotting (WB), ELISA

Product Details anti-SOCS1 Antibody (FITC)

Binding Specificity: AA 1-211

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Suppressor of cytokine signaling 1 protein (1-211AA)

Isotype: IgG

Application Details

Application Notes: Optimal working concentration should be determinde by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin^TM: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SOCS1

Target: SOCS1 (Suppressor of Cytokine Signaling 1 (SOCS1))

Alternative Name: SOCS1

Background:

Background: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival By similarity. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.

Aliases: CISH 1 antibody, CISH1 antibody, Cytokine inducible SH2 protein 1 antibody, JAB antibody, JAK binding protein antibody, JAK-binding protein antibody, Janus kinase binding protein antibody, SOCS 1 antibody, SOCS-1 antibody, Socs1 antibody, SOCS1_HUMAN antibody, SSI 1 antibody, SSI-1 antibody, SSI1 antibody, STAT induced STAT inhibitor 1 antibody, STAT-induced STAT inhibitor 1 antibody, Suppressor of cytokine signaling 1 antibody, Supressor of cytokine signalling 1 antibody, TEC interacting protein 3 antibody, Tec-interacting protein 3 antibody, TIP 3 antibody, TIP-3 antibody, TIP3 antibody

UniProt: O15524

Pathways: JAK-STAT Signaling, Interferon-gamma Pathway, TLR Signaling, Response to Growth Hormone Stimulus