TBK1 antibody

Catalog No. ABIN209092

This Mouse Monoclonal antibody specifically detects TBK1 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for TBK1 antibody (ABIN209092)

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This TBK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TBK1 Antibody

Specificity: NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphory.

Purification: Protein G purified

Immunogen:

Type of Immunogen: Native protein

Isotype: IgG1 kappa

Application Details

Application Notes: Approved: WB (1 - 2 μg/mL)

Usage: Suitable for use in Western Blot. Western Blot: 1-2 μg/mL.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.05 % BSA, 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Target Details for TBK1

Target: TBK1 (TANK-Binding Kinase 1 (TBK1))

Alternative Name: NAK / TBK1

Background: Name/Gene ID: TBK1
Subfamily: IKAPPAB
Family: Protein Kinase

Synonyms: TBK1, T2K, NAK, NF-kappa-B-activating kinase, NF-kB-activating kinase, TANK-binding kinase 1

Gene ID: 29110

UniProt: Q9UHD2

Pathways: TLR Signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome