Presenilin 1 antibody (AA 313-334)

Catalog No. ABIN211271

The Mouse Monoclonal anti-Presenilin 1 antibody has been validated for WB, ELISA and ICC. It is suitable to detect Presenilin 1 in samples from Human.

Quick Overview for Presenilin 1 antibody (AA 313-334) (ABIN211271)

Target: Presenilin 1 (PSEN1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Presenilin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-Presenilin 1 Antibody

Binding Specificity: AA 313-334

Specificity: Recognizes human, rat, mouse and primate presenilin 1. Detects a band of ~18kD (C-terminal fragment) and ~46kD (full-length) presenilin 1 by Western blot. Does not cross-react with presenilin 2.

Predicted Reactivity: Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%) Marmoset (91%).

Purification: Protein G purified

Immunogen: Synthetic peptide corresponding to aa 313-334 (S313KYNAESTERESQDTVAENDDG334) of C-terminal human presenilin 1. Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%), Marmoset (91%).

Type of Immunogen: Synthetic peptide

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA (1 μg/mL), ICC (6 μg/mL), WB (12 μg/mL)

Usage: Suitable for use in ELISA, Immunocytochemistry and Western Blot. ELISA: 1 μg/mL. Immunocytochemistry: 6 μg/mL. Western Blot: 12 μg/mL. Detects a band of ~18kD (C-terminal fragment) and ~46kD (full-length) presenilin 1.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 1 mg/mL BSA, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for Presenilin 1

Target: Presenilin 1 (PSEN1)

Alternative Name: PSEN1 / Presenilin 1

Background: Name/Gene ID: PSEN1
Subfamily: Aspartic A22A
Family: protease

Synonyms: PSEN1, AD3, Alzheimer disease 3, FAD, Protein S182, PS1, S182, PS-1, PSNL1, Presenilin 1, Presenilin-1

Gene ID: 5663

UniProt: P49768

Pathways: Notch Signaling, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport