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C3 antibody

C3 Reactivity: Human, Guinea Pig, Rabbit WB, IHC, IHC (fro) Host: Mouse Monoclonal H13 unconjugated
Catalog No. ABIN215710
  • Target See all C3 Antibodies
    C3 (Complement Component 3 (C3))
    Reactivity
    • 87
    • 54
    • 34
    • 4
    • 4
    • 4
    • 3
    • 2
    Human, Guinea Pig, Rabbit
    Host
    • 68
    • 43
    • 25
    • 8
    • 7
    • 5
    Mouse
    Clonality
    • 123
    • 32
    Monoclonal
    Conjugate
    • 65
    • 24
    • 23
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This C3 antibody is un-conjugated
    Application
    • 100
    • 49
    • 37
    • 33
    • 32
    • 29
    • 29
    • 26
    • 22
    • 17
    • 13
    • 12
    • 11
    • 9
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Specificity
    Recognizes a C3a-determinant (C3 alpha-chain) which is present also on native C3. Allows discrimination of ubiquitous or nonspecifically bound native C3 from biologically active C3b fragment, C3b or C are negative with this clone. The antibody inhibits the anaphylactic function of C3a: the capacity of C3a to induce serotonin release from thrombocytes in vitro is inhibited, similarly, treatment of C3a with the antibody inhibits the C3a-induced skin reaction in vivo. Species cross-reactivity: Guinea pig and rabbit C3/C3a.
    Purification
    Protein A purified
    Immunogen
    Human complement component C3.

    Type of Immunogen: Purified protein
    Clone
    H13
    Isotype
    IgG2b
    Top Product
    Discover our top product C3 Primary Antibody
  • Application Notes
    Approved: IHC, IHC-Fr, WB

    Usage: Suitable for use in Immunohistochemistry (frozen sections) and Western blotting. The antibody is, in combination with antibodies to the C3b fragment, an excellent control for distinguishing ubiquitous or nonspecifically bound native C3 from the biologically active C3 fragment. Nonactivated C3 still bears the C3a determinant, whereas activated C3 (C3b, C3d) is C3a-negative. It is therefore useful for immunopathological assays (demonstration of C3 deposition in biopsies) and for C3a assays research purposes.
    Comment

    Target Species of Antibody: Human

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    1 mL sterile ddH20
    Concentration
    Lot specific
    Buffer
    Lyophilized from PBS,  pH 7.4, 0.5 % BSA, 0.9 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Lyophilized and resuspended forms: store at -20°C.
  • Target
    C3 (Complement Component 3 (C3))
    Alternative Name
    Complement C3 (C3 Products)
    Synonyms
    AHUS5 antibody, ARMD9 antibody, ASP antibody, C3a antibody, C3b antibody, CPAMD1 antibody, AI255234 antibody, HSE-MSF antibody, Plp antibody, C3 antibody, C3-1 antibody, sb:cb26 antibody, si:dkey-76b14.4 antibody, wu:fi34b03 antibody, wu:fj86e11 antibody, C3d antibody, asp antibody, cpamd1 antibody, c3 antibody, complement C3 antibody, complement component 3 antibody, complement component c3a, duplicate 1 antibody, complement component 3 L homeolog antibody, complement component C3 antibody, complement C3-like antibody, C3 antibody, c3a.1 antibody, c3.L antibody, LOC443475 antibody, c3 antibody, c3-1 antibody, LOC100060539 antibody
    Background
    Name/Gene ID: C3

    Synonyms: C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3
    Gene ID
    718
    UniProt
    P01024
    Pathways
    Complement System, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling
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