TAB3 antibody (PE)

Catalog No. ABIN2179514

Product Details anti-TAB3 Antibody (PE)

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAB3 antibody is conjugated to PE

Application: Western Blotting (WB)

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TAB3

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for TAB3

Target: TAB3 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 3 (TAB3))

Alternative Name: Tab3 (TAB3 Products)

Synonyms: MAP3K7IP3 antibody, NAP1 antibody, 4921526G09Rik antibody, Map3k7ip3 antibody, mKIAA4135 antibody, map3k7ip3 antibody, nap1 antibody, tab3 antibody, tab3-a antibody, tab3-b antibody, map3k7ip3l antibody, si:ch211-232d19.8 antibody, si:dkey-30h22.6 antibody, TGF-beta activated kinase 1 and MAP3K7 binding protein 3 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 3 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 3 S homeolog antibody, TAB3 antibody, Tab3 antibody, tab3.S antibody, tab3 antibody

Background:

Synonyms: MAP3K7IP 3, Mitogen activated protein kinase kinase kinase 7 interacting protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, NAP1, NF kappa B activating protein 1, NF-kappa-B-activating protein 1, NFkB activating protein 1, TAB-3, TAB3, TAB3_HUMAN, TAK1 binding protein 3, TAK1-binding protein 3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, TGF-beta-activated kinase 1-binding protein 3.

Background: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene ID: 257397

UniProt: Q8N5C8

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades