Tryptophan Hydroxylase 2 antibody (pSer19)

Catalog No. ABIN2179763

The Rabbit Polyclonal anti-Tryptophan Hydroxylase 2 antibody has been validated for WB, ELISA, ICC, IF (cc), IF (p), IHC (p) and IHC (fro). It is suitable to detect Tryptophan Hydroxylase 2 in samples from Rat.

Quick Overview for Tryptophan Hydroxylase 2 antibody (pSer19) (ABIN2179763)

Target: Tryptophan Hydroxylase 2 (TPH2)

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tryptophan Hydroxylase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Tryptophan Hydroxylase 2 Antibody

Binding Specificity: pSer19

Cross-Reactivity: Rat

Predicted Reactivity: Human,Dog,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthesised phosphopeptide derived from human TPH2 around the phosphorylation site of Ser19

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for Tryptophan Hydroxylase 2

Target: Tryptophan Hydroxylase 2 (TPH2)

Alternative Name: TPH2

Background:

Synonyms: NTPH, ADHD7, Tryptophan 5-hydroxylase 2, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2, TPH2

Background: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]

Gene ID: 121278

UniProt: Q8IWU9