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PLVAP antibody

PLVAP Reactivity: Human WB, FACS, IHC (fro), IF Host: Mouse Monoclonal 174-2 unconjugated
Catalog No. ABIN2192062
  • Target See all PLVAP Antibodies
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    Reactivity
    • 27
    • 7
    • 1
    Human
    Host
    • 21
    • 6
    • 5
    Mouse
    Clonality
    • 22
    • 9
    Monoclonal
    Conjugate
    • 18
    • 5
    • 3
    • 2
    • 2
    • 2
    This PLVAP antibody is un-conjugated
    Application
    • 29
    • 21
    • 16
    • 9
    • 6
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    Sterility
    0.2 μm filtered
    Clone
    174-2
    Top Product
    Discover our top product PLVAP Primary Antibody
  • Application Notes
    For immunohistology, flow cytometry, immunofluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    Restrictions
    For Research Use only
  • Buffer
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Expiry Date
    12 months
  • Niemelä, Elima, Henttinen, Irjala, Salmi, Jalkanen: "Molecular identification of PAL-E, a widely used endothelial-cell marker." in: Blood, Vol. 106, Issue 10, pp. 3405-9, (2005) (PubMed).

    Carson-Walter, Hampton, Shue, Geynisman, Pillai, Sathanoori, Madden, Hamilton, Walter: "Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7643-50, (2005) (PubMed).

  • Target
    PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))
    Alternative Name
    Plasmalemma Vesicle Associated Protein (PLVAP Products)
    Synonyms
    MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody
    Background
    The monoclonal antibody 174/2 reacts with human plasmalemma vesicle associated protein (PLVAP), also known as PV1, PAL-E and FELS. PLVAP is a 60 kDa type II transmembrane glycoprotein which tends to form homodimers. PLVAP is widely expressed in the vasculature of normal tissues. The vascular staining pattern of PLVAP is quite unique among the endothelial cell antigens, since expression of other antigens (like ICAM-1, P-selectin, E-selectin or VCAM-1) is not limited to vascular endothelial cells. PLVAP expression in the vascular endothelial cells of the CNS is lost in association with formation of an intact blood-brain barrier. However, in the endothelium of human brain tumors expression of PLVAP is specifically up-regulated, making it a suitable antiangiogenic target for brain tumor therapy and cerebral edema. Furthermore, PLVAP is expressed in the vasculature of most other human tumors and as such useful as marker for tumor angiogenesis.
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