PLVAP antibody

Catalog No. ABIN298904

Product Details anti-PLVAP Antibody

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This PLVAP antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Recognizes murine plasmalemma vesicle-associated protein (PLVAP), a 60kD protein which is otherwise known as MECA-32 and PV-1. PLVAP is a transmembrane homodimer which is associated with endothelial cell caveolae and fenestrae. In adult and embryonic mice, PLVAP is primarily expressed on endothelial tissues but shows restricted distribution in the skeletal, cardiac and brain tissues. In embryonic mice, PLVAP expression, on the vasculature associated with blood brain barrier has been reported to be developmentally regulated. In humans, PLVAP is selectively up-regulated in a variety of high-grade brain tumors, including glioblastoma and metastatic carcinoma, as well as other cerebral disorders associated with blood-brain barrier disruption, such as acute ischemia. PLVAP represents a novel marker of brain tumor angiogenesis and integrity of the blood-brain barrier and is a potential therapeutic target.

Purification: Affinity purified

Immunogen:

Type of Immunogen: Native protein

Clone: MECA-32

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, IHC, IHC-Fr (1:25 - 1:100)

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze thaw cycles. Store undiluted.

Storage: 4 °C,-20 °C

Storage Comment: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.

References for anti-PLVAP antibody (ABIN298904)

Simon-Santamaria, Rinaldo, Kardas, Li, Malovic, Elvevold, McCourt, Smedsrød, Hirsch, Sørensen: "Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta." in: PLoS ONE, Vol. 9, Issue 11, pp. e111762, (2015) (PubMed).

Target Details for PLVAP

Target: PLVAP (Plasmalemma Vesicle Associated Protein (PLVAP))

Alternative Name: PV1 / PLVAP (PLVAP Products)

Synonyms: MECA32 antibody, Pv1 antibody, FELS antibody, PV-1 antibody, PV1 antibody, gp68 antibody, plasmalemma vesicle associated protein antibody, Plvap antibody, PLVAP antibody

Background: Name/Gene ID: PLVAP

Synonyms: PLVAP, gp68, FELS, Plasmalemma vesicle protein 1, PV-1, PV1

Gene ID: 83483

UniProt: Q9BX97