MEK1 antibody (pSer218, Ser222)

Catalog No. ABIN221121

This anti-MEK1 antibody is a Rabbit Polyclonal antibody detecting MEK1 in WB. Suitable for Human, Mouse, Rat, Dog, Cow, Chicken and Xenopus laevis.

Quick Overview for MEK1 antibody (pSer218, Ser222) (ABIN221121)

Target: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Reactivity: Human, Mouse, Rat, Dog, Cow, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MEK1 Antibody

Binding Specificity: pSer218, Ser222

Specificity: Specific for the ~45k MEK 1/2 protein phosphorylated at Ser218/222 in Western blots. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide

Purification: Immunoaffinity purified

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer218222 of human MEK 1/2. Note: The phosphosites in human MEK 1/2 are Ser218 and Ser222, the phosphosites in mouse MEK 1/2 are Ser217 and Ser221.

Application Details

Application Notes: Approved: WB (1:1000)

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: 50 μLof 10 mM HEPES,  pH 7.5, 150 mM sodium chloride, 0.1 mg/mL BSA, 50 % glycerol.

Storage: -20 °C

Storage Comment: Short term: -20°C
Long term: -20°C.

Target Details for MEK1

Target: MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

Alternative Name: MAP2K1 / MEK1

Background: Name/Gene ID: MAP2K1
Subfamily: MAP2K
Family: Protein Kinase

Synonyms: MAP2K1, ERK activator kinase 1, MAPK/ERK kinase 1, MAPKK 1, MKK1, PRKMK1, MEK 1, MAP kinase kinase 1, MAPKK1, MEK1

Gene ID: 5604

UniProt: Q02750

Pathways: MAPK Signaling, RTK Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling