HIP1 antibody (C-Term)

Catalog No. ABIN2443742

The Rabbit Polyclonal anti-HIP1 antibody is suitable to detect HIP1 in samples from Human and Rat. It has been validated for WB and IF.

Quick Overview for HIP1 antibody (C-Term) (ABIN2443742)

Target: HIP1 (Huntingtin Interacting Protein 1 (HIP1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HIP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-HIP1 Antibody

Binding Specificity: C-Term

Purpose: Huntingtin-Interacting Protein 1 (HIP1) Rabbit Polyclonal Antibody

Specificity: The antibody recognizes the C-terminal portion of HIP1

Purification: Purified

Immunogen: peptide in C term

Application Details

Application Notes: WB 1:500-1:2500,IF 1:10-1:100

Restrictions: For Research Use only

Handling

Reconstitution: If diluted with deionized water in 100 μL: WB 1:500-1:2500, IF 1:10-1:100. Optimal dilution has to be determined by the user.

Buffer: Immunogen affinity purified in glycerol/PBS pH 7.4

Preservative: Without preservative

Storage: 4 °C,-20 °C

Storage Comment: Antibodies diluted in glycerol can be kept at 4°C for up to 2 months and should be kept at -20°C for long-term storage (1 year). For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer. After the maximum long-term storage period (1 year -20°C or 2 months 4°C) antibodies should be tested in your assay with a standard sample to verify if you have noticed any decrease in their efficacy.

Expiry Date: 12 months

Target Details for HIP1

Target: HIP1 (Huntingtin Interacting Protein 1 (HIP1))

Alternative Name: Huntingtin-Interacting Protein 1 (HIP1)

Background:

HIP1

Hungtinton's disease (HD) is an inherited neurodegenerative disorder characterized by the expression of an expanded polyglutamine tract in the protein huntingtin. HIP1 (huntingtin interacting protein 1) binds to normal huntingtin but this interaction is lost in HD. HIP1 also binds to components of clathrin-coated pits and vesicles and is a marker of clathrin-coated membranes. HIP1 expression levels are altered in several types of cancer.

UniProt: O00291

Pathways: Positive Regulation of Endopeptidase Activity