G6PC antibody

Catalog No. ABIN2458824

Product Details anti-G6PC Antibody

Target: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Reactivity: Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This G6PC antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human G6PC.

Application Details

Application Notes: G6PC antibody can be used for detection of G6PC by ELISA at 1:62500. G6PC antibody can be used for detection of G6PC by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store G6PC antibody at -20 °C.

Target Details for G6PC

Target: G6PC (Glucose 6-Phosphatase, Catalytic (G6PC))

Alternative Name: G6PC (G6PC Products)

Background: G6PC hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum.It forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate to D-glucose and orthophosphate. It is a key enzyme in glucose homeostasis, functioning in gluconeogenesis and glycogenolysis. Defects in the enzyme cause glycogen storage disease type I (von Gierke disease). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Molecular Weight: 40 kDa

Gene ID: 2538

NCBI Accession: NP_000142

UniProt: P35575

Pathways: Carbohydrate Homeostasis, Cellular Glucan Metabolic Process