GALC antibody

Catalog No. ABIN2458899

Product Details anti-GALC Antibody

Target: GALC (Galactosylceramidase (GALC))

Reactivity: Human, Rat, Mouse, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GALC antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human GALC.

Application Details

Application Notes: GALC antibody can be used for detection of GALC by ELISA at 1:62500. GALC antibody can be used for detection of GALC by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store GALC antibody at -20 °C.

Target Details for GALC

Target: GALC (Galactosylceramidase (GALC))

Alternative Name: GALC (GALC Products)

Synonyms: 2310068B06Rik antibody, A930008M05Rik antibody, AW212969 antibody, AW413532 antibody, Gacy antibody, twi antibody, twitcher antibody, galc antibody, galcl antibody, zgc:92561 antibody, si:ch211-199l3.4 antibody, GALCERase antibody, wu:fi04e07 antibody, zgc:56444 antibody, galactosylceramidase antibody, galactosylceramidase a antibody, Galactosylceramidase antibody, galactosylceramidase L homeolog antibody, galactosylceramidase b antibody, GALC antibody, Galc antibody, galca antibody, galc antibody, Caci_7107 antibody, Bacsa_1415 antibody, Spico_0384 antibody, LOC100304802 antibody, galc.L antibody, galcb antibody

Background: GALC is a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy.This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molecular Weight: 73 kDa

Gene ID: 2581

NCBI Accession: NP_000144

UniProt: P54803