Klotho beta antibody

Catalog No. ABIN2459659

Product Details anti-Klotho beta Antibody

Target: Klotho beta (KLB)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Klotho beta antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KLB.

Application Details

Application Notes: KLB antibody can be used for detection of KLB by ELISA at 1:12500. KLB antibody can be used for detection of KLB by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store KLB antibody at -20 °C.

Target Details for Klotho beta

Target: Klotho beta (KLB)

Alternative Name: KLB (KLB Products)

Synonyms: KLB antibody, BKL antibody, AV071179 antibody, betaKlotho antibody, Klb-ps1 antibody, RGD1308227 antibody, klotho beta antibody, KLB antibody, Klb antibody

Background: KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.

Molecular Weight: 120 kDa

Gene ID: 152831

NCBI Accession: NP_783864

UniProt: Q86Z14

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Growth Factor Binding