TIAL1 antibody

Catalog No. ABIN2463661

Product Details anti-TIAL1 Antibody

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Reactivity: Human, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIAL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by protein A chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TIAL1.

Application Details

Application Notes: TIAL1 antibody can be used for detection of TIAL1 by ELISA at 1:62500. TIAL1 antibody can be used for detection of TIAL1 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store TIAL1 antibody at -20 °C.

Target Details for TIAL1

Target: TIAL1 (TIA1 Cytotoxic Granule-Associated RNA Binding Protein-Like 1 (TIAL1))

Alternative Name: TIAL1 (TIAL1 Products)

Synonyms: TCBP antibody, TIAR antibody, 5330433G13Rik antibody, AL033329 antibody, mTIAR antibody, zgc:66130 antibody, tcbp antibody, tiar antibody, TIA1 cytotoxic granule associated RNA binding protein like 1 antibody, Tia1 cytotoxic granule-associated RNA binding protein-like 1 antibody, TIA1 cytotoxic granule-associated RNA binding protein-like 1 antibody, TIAL1 antibody, Tial1 antibody, tial1 antibody

Background: The protein encoded by TIAL1 is a member of a family of RNA-binding proteins and possesses nucleolytic activity against cytotoxic lymphocyte target cells. The gene product is a cytotoxic granule-associated protein and has been shown to bind specifically to poly (A) homopolymers and to fragment DNA in permeabilized target cells. It has been suggested that members of this protein family may be involved in the induction of apoptosis. One isoform contains a lysosome-targeting motif in its C-terminal auxiliary domain, however, alternative splicing results in a T-cluster DNA-binding isoform, differing at the C-terminus where a hydrophobic sequence replaces the lysosome-targeting motif.

Molecular Weight: 42 kDa

Gene ID: 7073

NCBI Accession: NP_003243

UniProt: Q01085