BLK antibody (truncated)

Catalog No. ABIN2464018

Product Details anti-BLK Antibody

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Binding Specificity: truncated

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BLK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Immunogen: Ni-NTA purified truncated recombinant BLK expressed in E. Coli strain BL21 (DE3).

Clone: 9D10B7H6-9D10A8F8

Isotype: IgG1

Application Details

Application Notes: Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: -20 °C

Storage Comment: BLK monoclonal antibody can be stored at -20 °C, stable for one year.

Target Details for BLK

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Alternative Name: BLK (BLK Products)

Synonyms: bltk antibody, si:dkey-33i22.2 antibody, zgc:136231 antibody, MODY11 antibody, BLK proto-oncogene, Src family tyrosine kinase antibody, B lymphoid kinase antibody, blk antibody, BLK antibody, Blk antibody

Background: BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

Gene ID: 640

UniProt: P51451

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling