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SNCA antibody (truncated)
SNCA
Reactivity: Human
WB, ELISA, IHC
Host: Mouse
Monoclonal
2B2D1-2B2A11
unconjugated
Product Details anti-SNCA Antibody
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Target
See all SNCA Antibodies
SNCA
(Synuclein, alpha (SNCA))
Binding Specificity
All epitopes for SNCA antibodies
truncated
Reactivity
All reactivities for SNCA antibodies
Human
Host
All hosts for SNCA antibodies
Mouse
Clonality
All clonalities for SNCA antibodies
Monoclonal
Conjugate
All conjugates for SNCA antibodies
This SNCA antibody is un-conjugated
Application
All applications for SNCA antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Immunogen
Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3).
Clone
2B2D1-2B2A11
Top Product
Discover our top product SNCA Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot:1:500 - 1:2,000 IHC(P):1:500 - 1:2,000 IHC(F):1:500 - 1:2,000 ELISA:Propose dilution 1:10,000 Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage
-20 °C
Storage Comment
SNCA monoclonal antibody can be stored at -20 °C, stable for one year.
Target Details for SNCA
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Target
SNCA
(Synuclein, alpha (SNCA))
Alternative Name
SNCA (SNCA Products )
Synonyms
snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody
Background
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15 kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
Gene ID
6622
UniProt
P37840
Pathways
Synaptic Membrane , Regulation of G-Protein Coupled Receptor Protein Signaling , Positive Regulation of Endopeptidase Activity , Regulation of Carbohydrate Metabolic Process , Platelet-derived growth Factor Receptor Signaling , Negative Regulation of Transporter Activity , Regulation of long-term Neuronal Synaptic Plasticity
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