TYK2 antibody (truncated)

Catalog No. ABIN2464118

The Mouse Monoclonal anti-TYK2 antibody is suitable to detect TYK2 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for TYK2 antibody (truncated) (ABIN2464118)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 8G8E9-8G9H5

Product Details anti-TYK2 Antibody

Binding Specificity: truncated

Immunogen: Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3).

Isotype: IgG1

Application Details

Application Notes: Western Blot:1:500 - 1:2,000

ELISA:Propose dilution 1:10,000.

Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: -20 °C

Storage Comment: Tyk2 monoclonal antibody can be stored at -20 °C, stable for one year.

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: Tyk2

Background: Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.

Gene ID: 7297

UniProt: P29597

Pathways: JAK-STAT Signaling, Hepatitis C