Metabotropic Glutamate Receptor 5 antibody (N-Term)

Catalog No. ABIN2469508

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 5 in IHC. It exhibits reactivity toward Rat, Human, Mouse, Chicken, Dog, Monkey, Pig, Bat, Cow, Hamster, Horse, Rabbit and Gibbon.

Quick Overview for Metabotropic Glutamate Receptor 5 antibody (N-Term) (ABIN2469508)

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Reactivity: Rat, Human, Mouse, Chicken, Dog, Monkey, Pig, Bat, Cow, Hamster, Horse, Rabbit, Gibbon

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Metabotropic Glutamate Receptor 5 Antibody

Binding Specificity: N-Term

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: GRM5 antibody was raised against a peptide located in the N-Terminal extracellular domain of GRM5 (Human).

Application Details

Application Notes: GRM5 antibody can be used in Western Blot starting at 1:100, and immunohistochemistry starting at 1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: GRM5 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for Metabotropic Glutamate Receptor 5

Target: Metabotropic Glutamate Receptor 5 (GRM5) (Glutamate Receptor, Metabotropic 5 (GRM5))

Alternative Name: GRM5

Background: Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. GRM5 is involved in inflammatory mechanical hyperalgesia and potentially in schizophrenia

Gene ID: 2915

UniProt: P41594

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity