Metabotropic Glutamate Receptor 5 antibody (Glutamate Receptor, Metabotropic 5) (AA 824-1203)

Details for Product anti-GRM5 Antibody No. ABIN1686628
Antigen
  • GPRC1E
  • MGLUR5
  • mGlu5
  • mGluR5
  • mGlur5
  • 6430542K11Rik
  • AI850523
  • Glu5R
  • Gprc1e
  • mGluR5b
  • glutamate receptor, metabotropic 5
  • glutamate metabotropic receptor 5
  • GRM5
  • Grm5
Epitope
AA 824-1203
81
57
16
15
11
9
7
4
4
3
2
2
2
2
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
206
166
155
7
6
5
5
3
3
3
2
2
1
Host
Mouse
116
90
4
2
Clonality (Clone)
Monoclonal ()
Conjugate
This Metabotropic Glutamate Receptor 5 antibody is un-conjugated
12
10
7
6
6
6
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
175
111
81
67
56
39
37
22
13
5
4
3
2
1
Options
Immunogen Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b
Clone S75-3
Isotype IgG2a
Specificity Detects ~130 kDa (both mGluR1 and mGluR5).
Purification Protein G Purified
Plasmids, Primers & others Plasmids, Primers & others Metabotropic Glutamate Receptor 5 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name mGluR5 (GRM5 Antibody Abstract)
Background The AMPA receptor is a non-NMDA-type ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the CNS. AMPARs are composed of four types of subunits, designated as GluR1, GluR2, GluR3 and GluR4, which combine to form tetramers (1, 2).
Gene ID 24418
NCBI Accession NP_058708
UniProt P31424
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes
  • WB (1:1000)
  • IHC (1:1000)
  • ICC/IF (1:1000)
  • optimal dilutions for assays should be determined by the user.
Comment

1 μg/ml of ABIN1686628 was sufficient for detection of mGluR1/5 glutamate receptor in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Image no. 1 for anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (ABIN1686628) Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-mGluR1/5 glutamate r...
Image no. 2 for anti-Glutamate Receptor, Metabotropic 5 (GRM5) (AA 824-1203) antibody (ABIN1686628) Western Blot analysis of Rat Brain Membrane showing detection of ~130 kDa mGluR5 prot...
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