Connexin 43/GJA1 antibody (C-Term)

Catalog No. ABIN2469543

This anti-Connexin 43/GJA1 antibody is a Rabbit Polyclonal antibody detecting Connexin 43/GJA1 in IHC. Suitable for Human, Rat, Mouse, Dog, Cow, Monkey, Rabbit, Guinea Pig, Pig, Hamster, Gibbon and Gorilla.

Quick Overview for Connexin 43/GJA1 antibody (C-Term) (ABIN2469543)

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Reactivity: Human, Rat, Mouse, Dog, Cow, Monkey, Rabbit, Guinea Pig, Pig, Hamster, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Connexin 43/GJA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Connexin 43/GJA1 Antibody

Binding Specificity: C-Term

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: GJA1 antibody was raised against a peptide located in the C-Terminal domain of GJA1 (Human).

Application Details

Application Notes: GJA1 antibody can be used in ELISA, Western Blot starting at 1 - 2 μg/mL, immunohistochemistry starting at 10 μg/mL, immunocytochemistry, immunoprecipitation starting at 1 - 2 μg/mL, and flow cytometry starting at 1 - 2 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: GJA1 antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for Connexin 43/GJA1

Target: Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))

Alternative Name: GJA1

Background: Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is targeted by several protein kinases that regulate myocardial cell-cell coupling. A related intron-less connexin 43 pseudogene, GJA1P, has been mapped to chromosome 5.

Gene ID: 2697

UniProt: P17302

Pathways: MAPK Signaling, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization