BRCA1 antibody (N-Term)

Catalog No. ABIN2477707

This Mouse Monoclonal antibody specifically detects BRCA1 in WB, IF, IHC (p), IP, FACS and IHC (fro). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for BRCA1 antibody (N-Term) (ABIN2477707)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BRCA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: MS110

Product Details anti-BRCA1 Antibody

Binding Specificity: N-Term

Characteristics: Purified IgG

Purification: Purified

Immunogen: Recombinant protein corresponding to the N-Terminal region of human BRCA1

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

References for anti-BRCA1 antibody (ABIN2477707)

Milner, Wombwell, Eckersley, Barnes, Warwicker, Van Dorp, Rowlinson, Dearden, Hughes, Harbron, Wellings, Hodgson, Womack, Gray, Lau, OConnor, Marsden, Kvist: "Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours." in: Virchows Archiv : an international journal of pathology, Vol. 462, Issue 3, pp. 269-79, (2013) (PubMed).

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: BRCA1

Background: Synonyms: BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN

Gene ID: 672

UniProt: P38398

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus