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DLG4 antibody (PerCP)

This Mouse Monoclonal antibody specifically detects DLG4 in WB, IHC, ICC, IF and AA. It exhibits reactivity toward Rat.
Catalog No. ABIN2484819

Quick Overview for DLG4 antibody (PerCP) (ABIN2484819)

Target

See all DLG4 Antibodies
DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Reactivity

  • 140
  • 125
  • 120
  • 29
  • 18
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Rat

Host

  • 104
  • 72
  • 1
  • 1
  • 1
  • 1
Mouse

Clonality

  • 93
  • 85
  • 1
Monoclonal

Conjugate

  • 79
  • 9
  • 8
  • 8
  • 7
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
This DLG4 antibody is conjugated to PerCP

Application

  • 137
  • 82
  • 50
  • 41
  • 40
  • 40
  • 28
  • 27
  • 20
  • 19
  • 19
  • 16
  • 9
  • 2
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Antibody Array (AA)

Clone

6G6
  • Specificity

    Detects ~100 kDa. An additional protein of >100 kDa is also detected. Additional cross-reactive bands are detected at ~75 kDa and 50 kDa in rat and mouse samples.

    Cross-Reactivity

    Cow, Human, Mouse, Rat

    Purification

    Protein G Purified

    Immunogen

    Recombinant rat PSD-95

    Isotype

    IgG2a
  • Application Notes

    • WB (1:250)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.

    Comment

    1 μg/ml was sufficient for detection of PSD-95 on 20 μg rat brain tissue extract by ECL immunoblot analysis using Goat Anti-Mouse IgG: HRP as the secondary.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Conjugated antibodies should be stored at 4°C
  • Target

    DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

    Alternative Name

    PSD95

    Background

    Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4). PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).

    Gene ID

    29495

    NCBI Accession

    NP_062567

    UniProt

    P31016

    Pathways

    Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
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