SPPL2B antibody (N-Term)

Catalog No. ABIN2505859

The Rabbit Polyclonal anti-SPPL2B antibody (ABIN2505859) specifically detects SPPL2B in WB. The antibody is reactive with Human, Rat, Cow, Horse and Pig samples.

Quick Overview for SPPL2B antibody (N-Term) (ABIN2505859)

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reactivity: Human, Rat, Cow, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPPL2B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPPL2B Antibody

Binding Specificity: N-Term

Purpose: SPPL2B Antibody - N-terminal region

Sequence: AHLPHDLSKA SFLQLRNWTA SLLCSAADLP ARGFSNQIPL VARGNCTFYE

Predicted Reactivity: Cow: 79%, Horse: 86%, Human: 100%, Pig: 79%, Rat: 79%

Characteristics: This is a rabbit polyclonal antibody against SPPL2B. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N-terminal region of Human SPPL2B

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44988-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for SPPL2B

Target: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Alternative Name: SPPL2B

Background:

Background Information: SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.

Gene Name: signal peptide peptidase like 2B

Alternative Symbols: IMP4, PSH4, PSL1, IMP-4

Protein Name: Signal peptide peptidase-like 2B

Molecular Weight: 33kDa

Gene ID: 56928

NCBI Accession: NP_694533

UniProt: Q8TCT7