Fc epsilon RI/FCER1A antibody

Catalog No. ABIN2568133

The Hamster Monoclonal anti-Fc epsilon RI/FCER1A antibody (Clone FceR1) (ABIN2568133) specifically detects Fc epsilon RI/FCER1A in FACS, IHC, IP and Func. The antibody is reactive with Mouse samples.

Quick Overview for Fc epsilon RI/FCER1A antibody (ABIN2568133)

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This Fc epsilon RI/FCER1A antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Functional Studies (Func)

Clone: FceR1

Product Details anti-Fc epsilon RI/FCER1A Antibody

Specificity: The Mar-1 monoclonal antibody binds to the Fc ε Receptor I α subunit (FceR1a), which is a transmembrane glycoprotein from the immunoglobulin superfamily.

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Storage: 4 °C

Storage Comment: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Target Details for Fc epsilon RI/FCER1A

Target: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Alternative Name: Fc epsilon Receptor I alpha

Background: The Mar-1 monoclonal antibody binds to the Fc ε Receptor I α subunit (FceR1a), which is a transmembrane glycoprotein from the immunoglobulin superfamily. FceR1a lacks signal-transducing ability and is expressed by mast and basophil cells.The Fc ε Receptor I α subunit is upregulated by IgE and forms a tetramer with a beta subunit and two gamma subunits, which have ITAM (immunoreceptor tyrosine-based activation motifs). The complex formed by the four subunits has very important roles in the IgE-facilitated allergic reactions.

Gene ID: 2205

UniProt: P12319

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process