CSTB antibody (N-Term)

Catalog No. ABIN263931

The Mouse Monoclonal anti-CSTB antibody (Clone 2F1) (ABIN263931) specifically detects CSTB in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for CSTB antibody (N-Term) (ABIN263931)

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CSTB antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 2F1

Product Details anti-CSTB Antibody

Binding Specificity: AA 1-98, N-Term

Specificity: This antibody detetcts CSTB.

Characteristics: Synonyms: Stefin-B, CPI-B, CSTB, CST6, STFB, Liver thiol proteinase inhibitor

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human CSTB (1-98aa) purified from E. coli

Isotype: IgG2b

Application Details

Application Notes: ELISA. Western blot: 1: 1000 approx. 1: 3,000, starting diluton 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoidrepeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CSTB

Target: CSTB (Cystatin B (Stefin B) (CSTB))

Alternative Name: Cystatin-B

Background: CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to from a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes in cells. CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.Synonyms: CPI-B, CST6, CSTB, Liver thiol proteinase inhibitor, STFB, Stefin-B

Gene ID: 1476

UniProt: P04080

Pathways: Response to Water Deprivation