p107 antibody (N-Term)

Catalog No. ABIN264368

The Mouse Monoclonal anti-p107 antibody is suitable to detect p107 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for p107 antibody (N-Term) (ABIN264368)

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This p107 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: KAB6

Product Details anti-p107 Antibody

Binding Specificity: N-Term

Characteristics: Synonyms: Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1

Purification: Protein A/G chromatography

Purity: > 95 % by SDS-PAGE

Immunogen: GST fusion protein to the N terminus of p107. Genename: RBL1

Isotype: IgG1

Application Details

Application Notes: Suitable for Western Blots at 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Buffer: PBS containing 0.08 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Expiry Date: 12 months

Target Details for p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Alternative Name: RBL1

Background: P107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors.Synonyms: 107 kDa retinoblastoma-associated protein, Retinoblastoma-like protein 1, p107, pRb1

UniProt: P28749

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases