HHV8 antibody

Catalog No. ABIN264910

This Sheep Polyclonal antibody specifically detects HHV8 in WB and IP. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for HHV8 antibody (ABIN264910)

Target: HHV8 (Herpes Virus Type 8 (HHV8))

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This HHV8 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-HHV8 Antibody

Specificity: Cyclin

Purification: Ammonium Sulfate Precipitation

Immunogen: Inclusion Bodies from E. Coli expressing his-tagged full length Human cyclin G2 protein.

Isotype: IgG

Application Details

Application Notes: Immunoblotting: 1 - 5 μg/mL. Immunoprecipitation: 10 - 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 0.08 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

References for anti-HHV8 antibody (ABIN264910)

Anderton, Yee, Smith, Crook, White, Allday: "Two Epstein-Barr virus (EBV) oncoproteins cooperate to repress expression of the proapoptotic tumour-suppressor Bim: clues to the pathogenesis of Burkitt's lymphoma." in: Oncogene, Vol. 27, Issue 4, pp. 421-33, (2008) (PubMed).

Sugaya, Watanabe, Yang, Starost, Kobayashi, Atkins, Borris, Hanan, Schimel, Bryant, Roberts, Skobe, Staskus, Kaldis, Blauvelt: "Lymphatic dysfunction in transgenic mice expressing KSHV k-cyclin under the control of the VEGFR-3 promoter." in: Blood, Vol. 105, Issue 6, pp. 2356-63, (2005) (PubMed).

Järviluoma, Koopal, Räsänen, Mäkelä, Ojala: "KSHV viral cyclin binds to p27KIP1 in primary effusion lymphomas." in: Blood, Vol. 104, Issue 10, pp. 3349-54, (2004) (PubMed).

Target Details for HHV8

Target: HHV8 (Herpes Virus Type 8 (HHV8))

Alternative Name: Herpes Virus Type 8 / HHV8

Target Type: Virus

Background: Human herpervirus-8 (HHV-8) cyclin is a component of the HHV-8 virus particle. HHV8 has been found to be associated with three different diseases observed in AIDS patients, kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.Synonyms: HHV-8, KHSV

Molecular Weight: 28.1 kDa